Dr Peter O'Kane
Consultant Interventional Cardiologist
Specialties
Cardiology
Dr O'Kane graduated with a First Class Honours Bachelor of Science (BSc) degree in Physiology from the University of London and Medical Degree (MBBS) from Charing Cross & Westminster Medical School in 1995. He was award numerous prizes including the Llewelyn Prize for the second best distinction in medical finals. After attaining membership of the Royal College of Physicians (MRCP) during senior house officer training at Guy's Hospital he commenced specialty training in Cardiology as a research registrar at St Thomas' Hospital in 1998. He was subsequently awarded a Doctorate of Medicine (MD) by the University of London for a thesis on the role of nitric oxide in coronary heart disease. He trained in clinical cardiology on the South Thames NTN scheme working at Worthing Hospital, St Peter's Hospital Chertsey, and St George’s Hospital London before completing a 2-year sub-specialization program in Interventional Cardiology at St Thomas' supervised by Professor Simon Redwood. He was appointed as a Consultant Interventional Cardiologist at the Royal Bournemouth Hospital in July 2007. He was invited to become a Fellow of the Royal College of Physicians (FRCP) in 2012.
This is currently the UK's highest volume non-surgical PCI centre and he annually performs more than 500 PCI cases including participation in a 24 hour primary PCI service. The case mix is complex particularly amongst the many elderly patients who have multi-vessel coronary disease, which includes extensively calcified lesions, bifurcations including left main stem disease and chronic total occlusions. He performs some of the most complex PCI within the Department utilising specialist equipment and refined techniques.
What people can be referred for
Chest pain (angina pectoris)
Breathlessness
General Cardiology
Coronary Artery Disease - investigation and treatment
Complex percutaneous coronary intervention
Acute myocardial infarction - Heart Attack
Why I chose my specialties
Wide range of clinical conditions in this field with strong research based approach to investigation and therapies. Percutaneous coronary intervention (PCI) offers both symptom relief to improve quality and life saving opportunities.
Primary contact
Secretary: Janet Dryden
0300 019 4333
Membership of professional bodies
British Cardiovascular Society
British Cardiovascular Intervention Society
Fellow of Royal College of Physicians
British Medical Association
Year of registration
1995
Special clinical interests
He is committed to teaching and is a National Proctor for Rotational atherectomy, Optical Coherence Tomography (OCT) and Optical Frequency Domain Imaging (OFDI); European proctor for Laser atherectomy and International proctor for the Axxess dedicated bifurcation stent and Absorb bioresorbable vascular scaffold implantation. He is a member of the global expert network (GEN) for BRS technology and has participated in discussions with World Leaders in coronary intervention regarding this technology. He has developed and established a variety of local clinical teaching workshops and trained many Consultant colleagues from the UK and Internationally. He has also taught colleagues on site at catheter lab throughout the UK, Europe, Asia and the US in these multiple adjunctive devices in PCI, intra-coronary imaging and for the implantation techniques and rationale for use of Axxess stents and Absorb scaffolds. He is a member of the European Bifurcation Club and regular attender at the European CTO club.
Publications
2017
O'Kane P & Redwood S
Laser for PCI (Chapter 34)
Oxford Textbook of Interventional Cardiology 2nd Edition
Oxford University Press (In press)
Whittaker, A, Topaz O, O'Kane P
Lasers in Cardiology and Cardiothoracic Surgery
Lasers in Dermatology and Medicine, 2nd Edition (Book Chapter in Press with planned publication Jan 2017)
Springer Press
O'Kane P
Laser in CTO
Anterograde Chronic Total Occlusion iBook Eds
Spratt, Walsh & Hanratty (In press)
Longman K, Din J, Talwar S, O'Kane P
PCI in Centres without on-site cardiac surgery
Practical Interventional Cardiology, 3rd Edition Ed Ever Grech; Chapter 28, 377-392
CRC Press, Taylor & Francis Group, US
Asrress K, O'Kane P, Pyo R, Redwood S
Laser, Rotational and Orbital Atherectomy
Interventional Cardiology: Principles and Practice, 2nd Edition Eds Dangas G, Di Mario, C; Kipshidze N; Chapter 22, 224-232
Wiley-Blackwell, New York, US
Rawlins J, Din J, Talwar S, O'Kane P
Trans Radial Excimer Laser Coronary Atherectomy application during complex PCI
Transradial Approach for Percutaneous Interventions, 1st Edition Eds Zhou Y, Kiemeeij F, Liu W Chapter 24, 259-272
Springer Press, London
2016
Moss A, Dweck M, O'Kane P
A 56 year old woman with breathlessness
Heart 2016 doi:10.1136/heartjnl-2016-31061
Olechowski B, Fitzsimmons S, Thomas S, Richens T, O'Kane P
Image of the month: Aortic coarctation assessed by contemporary multimodality cardiac imaging
Clinical Medicine 2016;16(6): 1-3
Rawlins J, Din J, Talwar S, O'Kane P
Coronary Intervention with the Excimer Laser: Review of the technology and outcome data
Interventional Cardiology Review 2016;11(1): 27-32
Shah N, O'Kane P, Din J,
Late stent collapse identified with OCT - An underdiagnosed mechanism of restenosis?
Indian Heart Journal 2016), http://dx.doi.org/10.1016/j.ihj.2016.02.015
2015
Viswanathan GN, Din J, Swallow RA, Levy T, Talwar S, O'Kane P
Feasibility and Efficacy of Herculink Elite ((TM)) Biliary Stent Implantation in Large Coronary Arteries (= 5 mm) and Venous Conduits: An Observational Study.
Journal Interventional Cardiology 2015 28(4): 374-9/
Rawlins J, Din J, Talwar S, O'Kane P
Axxess Stent: Delivery Indications and Outcomes
Interventional Cardiology Review 2015; 10(2);85-9
Rawlins J, Talwar S, O'Kane P
Optical coherence tomography following percutaneous coronary intervention with Excimer laser coronary atherectomy
Lasers in Cardiovascular Interventions Ed On Topaz 2015; Chapter 8; 103-124
Springer Press, London
Rana O, Talwar S, O'Kane P
Excimer Coronary Laser Atherectomy during Percutaneous Coronary Intervention of Complex Lesions: Balloon Failures, Chronic Total Occlusions and Under-Expanded Stents
Lasers in Cardiovascular Interventions Ed On Topaz 2015; Chapter 3; 31-54
Springer Press, London
Whittaker A, Rawlins J, O'Kane P
Contemporary therapy of intracoronary thrombus: laser and bioresorbable scaffold
Cardiovasc Interv and Ther 2015 Jul 30(3); 277-8
Rana O, Sastry S, Fath-Ordoubadi F, Mamas M, Talwar S, Din, J, O'Kane P
World's First Series of Left Main Bifurcation Treated with The Axxess 4.0x9mm Dedicated Bifurcation Stent
Journal of the American College of Cardiology 2014; 64 (11-S)
Rana O, Shah NC, Wilson S, Swallow R, O'Kane P, Levy T
The Impact of Routine and Intravascular Ultrasound-Guided High-Pressure Postdilatation After Drug-Eluting Stent Deployment: The STent OPtimization (STOP) Study.
J Invasive Cardiol. 2014 Dec;26(12):640-6.
Kwok CS, Anderson SG, McAllister KS, Sperrin M, O'Kane PD, Keavney B, Nolan J, Myint PK, Zaman A, Buchan I, Ludman PF, de Belder MA, Mamas MA; on behalf of the British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.
Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society.
Catheter Cardiovasc Interv. 2014 Nov 19 doi: 10.1002/ccd.25732. [Epub ahead of print]
Mauri L, Kereiakes DJ, Yeh RW, Driscoll-Shempp P, Cutlip DE, Steg PG, Normand SL, Braunwald E, Wiviott SD, Cohen DJ, Holmes DR Jr, Krucoff MW, Hermiller J, Dauerman HL, Simon DI, Kandzari DE, Garratt KN, Lee DP, Pow TK, Ver Lee P, Rinaldi MJ, Massaro JM; DAPT Study Investigators.
Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.
N Engl J Med. 2014 Dec 4;371(23):2155-66. doi: 10.1056/NEJMoa1409312. Epub 2014 Nov 16
Mamas MA, Anderson SG, O'Kane PD, Keavney B, Nolan J, Oldroyd KG, Perera D, Redwood S, Zaman A, Ludman PF, de Belder MA; British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.
Impact of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society.
Eur Heart J. 2014 Nov 14;35(43):3004-12a. doi: 10.1093/eurheartj/ehu303. Epub 2014 Aug 28
2013
Shah N, Rana O, Fath-Ordoubadi F, Sastry S, Mamas, M, Talwar S, Din J, O'Kane P
Early UK Experience of the Axxess Dedicated Bifurcation Stent
Journal of the American College of Cardiology 2013; 62 (18-S1)
de Belder A, Hernandez JMT, Lopez-Palop R, O'Kane P, Hernandez Hernandez F, Strange J, Gimeno F, Cotton J, Diaz Fernandez JF, Carrillo Saez P, Thomas M, Pinar E, Curzen N, Baz JA, Cooter N, Lozano I, Skipper N, Robinson D, Hildick-Smith D; XIMA Investigators.
A prospective randomized trial of Everolimus-eluting stents versus bare metal stents in Octogenarians: Xience or Vision stents for the Management of Angina in the Elderly – The XIMA Trial
Journal of the American College of Cardiology doi:10.1016/j.jacc.2013.10.053
Rawlins J, Talwar S, Green M, O'Kane P
Optical coherence tomography following percutaneous coronary intervention with Excimer laser coronary atherectomy
Cardiovascular Revascularisation Medicine 2013 (in Press)
Sambu N, Fernandez J, Shah N, O'Kane P
The Guideliner Catheter: An Interventionist's Experience of their first 50 cases - "The Mostly Good, rarely Bad, Beware of the Ugly!"
Interventional Cardiology 2013; 5 (4) 389-405
Rawlins J, Shah N & O'Kane P
Strategies for the management of massive Intra-coronary thrombus in acute myocardial infarction
Heart 2013; 99: 510 doi: 10. 1136/heartjnl-2012-303370
Rana O, Moran R, O'Kane P, Boyd S, Swallow, Talwar S, Levy T
Percutaneous coronary intervention in the very elderly (>85 years): trends and outcomes
British Journal of Cardiology Jan-Mar 2013 20 (1) 27-31
Rawlins J, Shah N, Talwar S & O'Kane P
How to untie a transfemoral catheter knot with a Lasso from the transradial approach
British Journal of Cardiology Jan-Mar 2013 20 (1) 38
Fernandez JP, Hobson AR, McKenzie D, Talwar S, O'Kane P
Beyond the Balloon: Excimer coronary laser atherectomy used alone or in combination with rotational atherectomy in the treatment of chronic total occlusions, non-crossable and non-expansible coronary lesions
Eurointervention 2013; 9 (2) 243-250
Rawlins J, Shah N & O'Kane P
Adjuvant Interventional techniques for the treatment of intra-coronary thrombus
Heart 2012; Heart. 2012 Nov 22 0:1. Doi:10.1136/heartjnl-2012-303157
Bowers R, O'Kane P & Balasubramaniam RN
Type 1 Brugada ECG unmasked by intracoronary contrast media
Heart 2013 Jan;99(2):147-8
2012
Rawlins J, Shah N & O'Kane P
Contempoary clot busting in STEMI: beware the thrombus
Heart 2012 Aug;98(16):1259-60
George SK, Ramtohal RL, Ponnampura C, Radvan J, Bull R, O'Kane P
'New World' imaging for an 'Old World' disease: Use of Cardiac MRI & 3D transoesophageal echocardiography in severe rheumatic mitral valve disease
Journal of Cardiology Cases 2012 (6) e4-e7 http://dx.doi.org/10.1016/j.jccase.2012.02.005
2011
Fernandez JP, Hobson AR, McKenzie D, Talwar S, O'Kane P
Excimer Laser Coronary Atherectomy: A Novel Strategy to Aid Management of Stent Underexpansion
Eurointervention 2011; 7(3): 400-407
Child N, Fernandez JP, O'Kane P
Radial artery sheath reaction treated with oral steroids
BMJ 2011; 342:d1287
McKenzie D, Talwar S, Jokhi P, O'Kane P
How should I treat severe coronary artery calcification when it is not possible to dilate a balloon or deliver a RotaWire™?
Eurointervention 2011; 6(6): 779-783
2010
Fernandez JP, Hobson AR, McKenzie D, Talwar S, O'Kane P
Treatment of calcific coronary stenosis with the use of excimer laser coronary atherectomy and rotational atherectomy
Interventional Cardiology 2010 2(6) 801-806
Jokhi P & O'Kane P
Induction of mechanical and ST-T alternans following angioplasty in severe heart failure
Eurointervention 2010; 6(1): 171
2009
O'Kane P & Redwood S
Laser for PCI (Chapter 34)
Oxford Textbook of Interventional Cardiology
Oxford University Press, 2010
Jokhi PP, McKenzie D, O'Kane P
Use of a novel pericardial covered stent to seal an iatrogenic perforation
Journal of Invasive Cardiology 2009; 21(10): E187-90
O'Kane P, Xie L, Liu Z, Queen L, Jackson G, Yong J & Ferro A.
Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity
Cardiovascular Research 2009; 83: 131-139
2008
Lockie T, Perera D, O'Kane P, Hartley S, Khan S, Webb I, Redwood S
Deferral of coronary intervention on the basis of fractional flow reserve measurement: a real-world analysis
Cardiovascular Revascularization Medicine 2008; 9 (3), 199-200
Jokhi P, Talwar S, O'Kane P
Use of laser atherectomy and IVUS guidance during PCI on a saphenous vein bypass graft with subacute total occlusion
Eurointervention 2008; 4 (Web)
O'Kane P, Reebye V, Yong J, Stratton P, Jackson G, Ferro A
Aspirin and clopidogrel treatment impair nitric oxide biosynthesis by platelets
Journal Molecular & Cellular Cardiology 2008 45; 223-229
O'Kane P, Jackson G & Ferro A.
Whole body nitric oxide production is not decreased in patients with coronary atherosclerosis but is inversely related to plasma homocysteine
Atherosclerosis: 2008; 196 574-579
2007
O'Kane P, Blows L, & Redwood S
New Devices Illustrated: The Venture Wire Control Catheter
The British Journal of Cardiology 14 (6) 293-295
2003
O'Kane P & Jackson G
Atrial fibrillation (Review)
In: M Selby (ed) Clinical General Practice, vol. 1, Ch. 9, pp 43–48.
Butterworth Heinemann, Edinburgh, 2004
2002
O'Kane P, Queen L, Stratton P, Jackson G & Ferro A.
Aspirin modifies nitric oxide synthase activity in platelets: effects of acute versus chronic aspirin treatment
Cardiovascular Research 2003; 59; 152-9
2001
O'Kane P & Jackson G.
Cardiovascular Disease in the Elderly (Review)
Chapter 13 for Cardiology: Current Perspectives, Martin Dunitz, London 2002
O'Kane P & Jackson G.
Erectile dysfunction: Is there underlying obstructive coronary artery disease?
International Journal of Clinical Practice 2001; 55(3):219-220 (80 Citations)
2000
O'Kane P & Jackson G.
Biochemical Assays in Acute Coronary Syndrome (Editorial)
Emirates Medical Journal 2000; 18(3) 173-176
O'Kane P & Jackson G.
Atrial Fibrillation: an update (Review)
Update February 2000; 241-249
O'Kane P & Jackson G.
ESC Meeting Report - Sexual Activity and the Cardiac Patient
Sexual Dysfunction in Medicine 2000; 1(3): 92-94
1999
O'Kane P & Jackson G.
Cardiovascular Disease in the Elderly (Review)
Practitioner 1999 Jul; 243(1600):574-80
Outcome data
Research
He has published over 45 manuscripts in the last 17 years including original work, international collaboration and case studies. He has authored 10 book chapters particularly related to Laser atherectomy. He is regularly invited as faculty to National and International meetings as a presenter and live case operator and has performed many live cases at Bournemouth and at other centres in the UK and in Europe. He is a local principal Investigator for more than 10 National and International multi-centre clinical trials and is dedicated to patient recruitment to studies, which ultimately determine best practice guidelines and improve clinical outcome. Within the Directorate of Cardiology he has led numerous quality improvement programs and has achieved local clinical excellence award level 5.
