Dr Simon McLaughlin
Consultant Physician and Gastroenterologist
Specialties
Gastroenterology
General Medicine
Dr McLaughlin trained in Medicine at Guy's, King's and St. Thomas' Medical Schools, qualifying in 2000. During his postgraduate training he undertook two and half years of clinical research at St. Mark's and St. Thomas' Hospitals London. His research investigated the hypothesis that a bacterial dysbiosis is fundamental to the inflammatory process which occurs in up to half of patients with ulcerative colitis who undergo restorative proctocolectomy. Further work included developing new treatment strategies for pre-pouch ileitis and pouchitis in patients with ulcerative colitis. He was awarded an MD from Imperial College London in 2010.
Dr McLaughlin has undertaken additional specialist training in single-balloon and device assisted enteroscopy and also video-capsule endoscopy at St. Thomas' Hospital London. He remains actively involved in research at Bournemouth University where he is a Visiting Fellow and also within the hospital setting where he is the clinical lead for research in gastroenterology at the Royal Bournemouth hospital.
Dr McLaughlin has published three book chapters on inflammatory bowel disease and has written numerous papers, he authored the 2010 British Society of Gastroenterology Coeliac Disease guidelines. His practice includes all aspects of luminal gastroenterology with a particular interest in inflammatory bowel disease (Crohn's disease, ulcerative colitis and patients who have undergone ileal-anal pouch surgery) irritable bowel syndrome and coeliac disease. His endoscopic interests include small bowel video capsule endoscopy, small bowel enteroscopy as well as gastroscopy and colonoscopy.
What people can be referred for
Ulcerative colitis
Crohn's disease
Pouchitis
Microscopic colitis
Coeliac disease
Why I chose my specialties
My specialty allows me to see a broad range of patients often with difficult symptoms. It is satisfying to be able to talk freely about what are often embarrassing symptoms. The number of treatments that are now available mean that usually we can treat patients without the need for surgery.
Membership of professional bodies
GMC
Royal College of Physicians
British Society of Gastroenterology
American Gastroenterology Association
Year of registration
2000
Special clinical interests
Ulcerative colitis
Crohn's disease
Pouchitis
Microscopic colitis
Coeliac disease
Areas of speacial interest
Inflammatory bowel disease Coeliac disease Nutrition Minimally invasive gastroenterology; capsule endoscopy. Complex therapeutic colonoscopy; EMR, FTRD Balloon enteroscopy
About Simon McLaughlin
Dr McLaughlin trained in Medicine at Guy’s, King’s and St. Thomas’ Medical Schools, qualifying in 2000. During his postgraduate training he undertook two and half years of clinical research at St. Mark’s and St. Thomas’ Hospitals London his work included developing new treatment strategies for pre-pouch ileitis and pouchitis in patients with ulcerative colitis. Dr McLaughlin has published three book chapters on inflammatory bowel disease and has written numerous papers, he authored the 2010 British Society of Gastroenterology Coeliac Disease guidelines. Dr McLaughlin became a consultant in 2010 and remains actively involved in research within the hospital setting where he is the clinical lead for research in gastroenterology at the Royal Bournemouth hospital. He is a Visiting Fellow at Bournemouth University. Outside work he enjoys keeping fit and spending time outdoors; swimming, cycling and sailing with his family.
Publications
Original articles
1. Segal JP, Stephanie Poo, McLaughlin SD, Faiz OD, Clark SK, Hart AL
Long term follow-up of the use of maintenance antibiotic therapy for chronic antibiotic dependent pouchitis
Frontline Gastroenterology in press 2018
2. Selinger CP, Parkes GC, Bassi A, Fogden E, Hayee B, Limdi JK, Ludlow H, McLaughlin S, Patel P, Smith M, Raine T.
A multi-centre audit of excess steroid use in 1176 patients with inflammatory bowel disease
Aliment.Pharmacol.Ther. in press 2017
3. Incidence and long term implications of pre-pouch ileitis. An observational study
Segal JP, McLaughlin SD, Faiz OD, Clark SK, Hart AL
Dis. Colon and Rectum. In press 2017
4. Coulthard SA, Berry P, McGarrity S, McLaughlin S, Ansari A, Redfern CPF
Azathioprine with Allopurinol: Lower Deoxythioguanine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone
Inflamm. Bowel Dis. April 2017
5. J. Landy, A. W. Walker, J. V. Li, H. O. Al-Hassi, E. Ronde, N. R. English, E. R. Mann, D. Bernardo, S. D. McLaughlin, J. Parkhill, P. J. Ciclitira, S. K. Clark, S. C. Knight & A. L. Hart
Variable alterations of the microbiota, without metabolic or immunological change, following faecal microbiota transplantation in patients with chronic pouchitis
Sci. Rep. 2015 Aug 12;5:12955
6. Dharmasiri S, Dewhurst H, Johnson H, Weaver S, McLaughlin SD
Low dose thiopurine and allopurinol co-therapy results in significant cost savings at a district general hospital
Frontline Gastroenterology Oct. 2015 Vol. 6 Issue 4.
7. Al-Shamma S, Eross B, McLaughlin SD,
Use of a xanthine oxidase inhibitor in autoimmune hepatitis
Hepatology. 2013 Mar;57(3):1281-2 Epub 2013 Feb 4
8. McLaughlin SD, Culkin A, Cole, J, Clark SK, Tekkis PP, Ciclitira PJ, Nicholls RJ, Whelan K
Exclusive elemental diet impacts on the gastrointestinal microbiota and improves symptoms in patients with chronic pouchitis
Journal of Crohn’s and Colitis 2013 Jul;7(6):460-6.
9. McLaughlin SD, Clark SK, Roberts CH, Perry-Woodford ZL, Tekkis PP, Ciclitira PJ, Nicholls RJ
Extended spectrum beta-lactamase producing bacteria and Clostridium difficile in pouchitis patients
Aliment.Pharmacol.Ther 2010 Sep;32(5):664-9.
10. McLaughlin SD, Walker A, Churcher C, Clark SK, Tekkis PP, Johnson MW, Parkhill J, Ciclitira PJ, Dougan G, Nicholls RJ, Petrovska L
The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing
Ann Surg. 2010 Jul;252(1):90-8.
11. McLaughlin SD, Clark SK, Tekkis PP, Ciclitira PJ, Nicholls RJ
An open study of maintenance antibiotic therapy for Chronic Antibiotic Dependent Pouchitis; efficacy, complications and outcome
Colorectal Dis. 2011 Apr;13(4):438-44.
12. Maeda Y, Molina M, Norton C, McLaughlin SD, Laurberg S, Clark SK
The role of pouch compliance measurement in the management of pouch dysfunction
Int J Colorectal Dis. 2009 Nov 19.
13. McLaughlin SD, Perry-Woodford ZL, Johnson MW, Clark SK, Tekkis PP, Ciclitira PJ, Nicholls RJ
Osteoporosis in patients over 50 years of age following restorative proctocolectomy for ulcerative colitis: is DXA screening warranted?
Inflamm. Bowel Dis. 2010 Feb;16(2):250-5.
14. McLaughlin SD, Clark SK, Shafi S, Petrovksa L, Tekkis PP, Ciclitira PJ, Nicholls RJ.
Fecal coliform testing to identify effective antibiotic therapies for patients with antibiotic-resistant pouchitis.
Clin Gastroenterol Hepatol 2009;7:545-548
15. McLaughlin SD, Clark SK, Bell AJ et al.
Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.
Dis. Colon Rectum 2009;52(5):879-83.
16. McLaughlin SD, Clark SK, Bell AJ, Tekkis PP, Ciclitira PJ, Nicholls RJ
An open study of antibiotics for the treatment of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis
Aliment Pharmacol Ther. 2009 Jan;29(1):69-74
17. Maiden L, Elliott T, McLaughlin SD, Ciclitira P
A Blinded Pilot Comparison of Capsule Endoscopy and Small Bowel Histology in Unresponsive Coeliac Disease
Digestive Dis. Sci. 2009 Jun;54(6):1280-3.
Review Articles
1. Segal J, Ding N, Worley G, McLaughlin S, Preston S, Faiz O, Clark S, Hart A
Systematic Review with meta-analysis - management of chronic refractory pouchitis with an evidence-based treatment algorithm.
Alimentary Pharmacology & therapeutics 2017 Mar;45(5):581-592
2. Dewar DH, Donnelly SC, McLaughlin SD, Johnson MW, Ellis HJ, Ciclitira PJ
Celiac disease: Management of persistent symptoms in patients on a gluten-free diet
World Journal of Gastroenterology 2012 Mar 28;18(12):1348-56
3. Landy J, Al-Hassi HO, McLaughlin SD, Walker AW, Ciclitira PJ, Nicholls RJ, Clark SK, Hart AL
The etiology of pouchitis
Inflamm. Bowel Dis. 2012 Jun;18(6):1146-55
4. Landy J, Al-Hassi HO, McLaughlin SD, Walker AW, Ciclitira PJ, Nicholls RJ, Clark SK, Hart AL
Review article: faecal transplantation therapy for gastrointestinal disease
Aliment.Pharmacol.Ther 2011 Aug;34(4):409-415.
5. McLaughlin SD, Clark SK, Tekkis PP, Nicholls RJ, Ciclitira PJ
The bacterial pathogenesis and treatment of pouchitis
Therapeutic Advances in Gastroenterology. 2010 3: 335
6. Perry-Woodford ZL, McLaughlin SD
Ileoanal pouch dysfunction and the use of a medena catheter following hospital discharge
British Journal of Community Nursing. 14(11): 502 - 506 (Nov 2009)
7. McLaughlin SD, Clark SK., Thomas-Gibson S, Tekkis PP, Ciclitira PJ, Nicholls RJ
A guide to endoscopy of the Ileo-anal pouch following restorative proctocolectomy with ileal pouch-anal anastomosis; Indications, technique and management of common findings
Inflamm. Bowel Dis. 2009 Aug;15(8):1256-63
8. McLaughlin SD, Clark SK
Ileal pouch-anal anastomosis (IPAA) for ulcerative colitis; management of complications and follow up in primary care
Practical Gastroenterol. August 2008
9. McLaughlin SD, Clark SK., Tekkis PP, Ciclitira PJ, Nicholls RJ
Review Article: Restorative Proctocolectomy, Indications, Management of Complications and Follow-Up: a Guide for Gastroenterologists.
Aliment.Pharmacol.Ther. 2008 May;27(10):895-909.
10. Perry-Woodford ZL, McLaughlin SD
Recommended Follow-Up for the Ileo-anal Pouch Patient, From Ward Discharge to a Nurse-Led Clinic
British Journal of Nursing Vol. 17 (4), 2008
11. Perry-Woodford ZL, McLaughlin SD
The Nurse specialists guide to ileo-anal pouch surgery and related complications
Gastrointestinal Nursing, Vol. 5, Iss. 4, 17 May 2007, pp 18 – 24
Research
I am clinical lead for research in gastroenterology and am the principal investigator for a number of studies in Inflammatory bowel disease.
I am also involved in ongoing research into treatments for and causes of Pouchitis at St. Mark's hospital London.
