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Medications in Parkinson’s

To improve the movement difficulties caused by Parkinson’s, drug treatments aim to increase the level of dopamine that reaches the brain, and/or to stimulate the parts of the brain where dopamine works.

Different drugs may be used for different people depending on symptoms. Medication options will be discussed by the Parkinson’s Specialist.

Please note that the following information is only a very brief guide. For more information about Parkinson’s medications, please click here.

Dopaminergic drug treatments in Parkinson’s

There are four main classes of dopaminergic drug that can be used in the management of Parkinson symptoms:

Levodopa

Dopamine agonists

MAO-B inhibitors

COMT inhibitors


 

Treatment Name

Generic name

How it works

Levodopa​

  • Co-careldopa (Sinemet® preparations)

  • Co-beneldopa (Madopar® preparations)

  • Stalevo®

  • Stanek® (co-careldopa plus entacapone)

Causes the nerve cells to make more dopamine

Dopamine Agonist

  • Ropinirole

  • Pramipexole

  • Rotigotine

Mimics the way that dopamine works

MAO-B inhibitors

  • Rasagaline

  • Selegiline

  • Safinamide

Stops an enzyme using up dopamine, so more is available

COMT inhibitors​

  • Entacapone

  • Opicapone

  • Co-careldopa and entacapone

Block an enzyme that breaks down Levodopa

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