Autoimmune Repertoire
- Contact Information
- Immunology Re-test Interval
- Specimen Referrals
- Request Forms
- Clinical Advice
- Additional Requests/ Follow Up Testing
- Investigations
- Specimen Requirements
- Common Indicators
- Allergy Repertoire
- Autoimmune Repertoire
- Antibodies to Nuclear Components
- Organ Specific Antibodies
- Specific IgG Testing
Tests outside the Immunology repertoire will be processed on a case by case basis
Please be aware that some of the following tests are confirmatory tests and their TAT reflects this
e.g. Endomysial antibody testing is performed following a first-time positive Tissue Transglutaminase antibody result or GAD testing performed first and IA2 testing completed if GAD result is negative.
|
Test Name |
Relevance |
Turn around time in days |
|---|---|---|
|
Acetylcholine Receptor Abs |
Myasthenia Gravis |
21 days |
|
Adrenal Abs |
Addisonian adrenal insufficiency |
28 days |
|
Anti-β2-Glycoprotein IgG Abs |
Antiphospholipid syndrome |
7 days |
|
Anti-Centromere Abs |
CREST |
24 days |
|
Anti-Cyclic Citrullinated Peptide Antibody |
Rheumatoid Arthritis |
7 days |
|
Anti-nuclear Abs (connective tissue screen) |
Connective tissue disease |
7 days |
|
Anti-thyroid peroxidase Abs TPO |
Graves’ and Hashimoto’s |
7 days |
|
Voltage-gated calcium channel Abs |
Lambert Eaton myasthenic syndrome |
28 days |
|
Voltage-gated potassium channel Abs
CASPR2 and LGI1 |
Neurological disorders |
28 days |
|
Aquaporin-4 Abs |
Neuromyelitis optica |
28 days |
|
AP50 |
Alternative haemolytic complement assay |
28 days |
|
Liver autoimmune profile |
ANA – connective tissue disease |
10 days |
|
|
Liver / kidney microsomal Abs – Autoimmune hepatitis |
|
|
|
Mitochondria Abs- PBC |
|
|
|
Smooth muscle Abs- chronic active hepatitis |
|
|
Bronchiectasis |
Bronchiectasis screen |
40 days |
|
CH50 |
Haemolytic complement assay – classical pathway (liposomal method) |
28 days |
|
C1-esterase |
C1-Esterase inhibitor deficiency |
28 days |
|
C1-esterase functional |
C1-Esterase inhibitor deficiency |
56 days |
|
Anti- C1Q Abs |
Hypocomplementaemic Urticarial Vasculitis (HUV), Systemic Lupus Erythematosus(SLE)and Lupus Nephritis |
28 days |
|
C1Q level |
Differential diagnosis of acquired angioedema. Low levels can be seen in SLE, glomerulonephritis and recurrent infections |
28 days |
|
Cardiolipin IgG / IgM |
Antiphospholipid syndrome |
7 days |
|
Calprotectin |
Differentiates between Inflammatory Bowel Diseases, Crohn’s Disease and Ulcerative Colitis and other bowel diseases |
10 days |
|
Connective Tissue Disease (CTD) Screen |
Panel contains the following auto antibodies: |
7 days |
|
U1-snRNP |
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|
Sm |
||
|
SS-A/Ro |
||
|
SS-B/La |
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|
Centromere |
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|
Jo-1 |
||
|
SCL-70 |
||
|
dsDNA |
||
|
Fibrillarin |
||
|
RNA Pol III |
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|
Rib-P |
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|
PM-Scl |
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|
PCNA |
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|
Mi-2 |
||
|
SmD |
||
|
Direct immunofluorescence (skin biopsies) |
Skin biopsy investigation for bullous disease,SLE, DH, EBA, Lichen planus |
14 days |
|
Double stranded DNA Abs |
SLE |
14 days |
|
Extractable nuclear antigens |
Screen |
14 days |
|
|
Ro – Sjogren’s, SLE |
|
|
|
La- Sjogren’s, SLE |
|
|
|
Sm – SLE specific |
|
|
|
RNP- MCTD, SLE |
|
|
|
Jo-1 – Polymyositis |
|
|
|
Scl-70 – Scleroderma |
|
|
Endomysial Abs (IgA) |
Coeliac Disease |
14 days |
|
Glomerular Basement Abs (GBM) |
Goodpasture’s Syndrome |
7 days |
|
Anti-Glutamic acid decarboxylase Abs (GAD) |
Type I diabetes and stiff mans syndrome |
28 days |
|
Anti-GM1 & GQ1B Abs |
Anti-ganglioside antibodies |
28 days |
|
Intrinsic Factor Abs |
Pernicious Anaemia |
14 days |
|
IA2 antibodies |
Type I diabetes |
56 days |
|
IGG subclasses / IGG4 |
Autoimmune pancreatitis and IgG4 associated diseases |
28 days |
|
Anti-MUSK |
Myasthenia Gravis |
49 days |
|
Mitochondrial 2 Abs (M2) |
Primary biliary cirrhosis |
14 days |
|
Anti-myelin associated glycoprotein Abs (MAG) |
Adult onset neuropathy |
28 days |
|
Fixed Cell NMDA receptor Abs |
Neurological disorders |
28 days |
|
Ovarian Abs |
Primary autoimmune ovarian failure |
28 days |
|
Myeloperoxidase Abs (MPO) |
(P-ANCA) Vasculitis |
Urgent 1 day, routine 7 days |
|
Proteinase 3 Abs (PR3) |
(C-ANCA) Granulomatosis with polyangiitis |
Urgent 1 day, routine 7 days |
|
Paraneoplastic Abs (includes Yo, Hu, Ri Antibodies) |
Paraneoplastic syndromes |
28 days |
|
Skin Abs |
Pemphigoid (Basement membrane – BM), Pemphigus. |
9 days |
|
Tissue Transglutaminase IgA |
Coeliac Disease |
7 days |
|
Tissue Transglutaminase IgG |
Coeliac Disease |
7 days |
|
TSH Receptor Antibodies |
Grave’s Disease |
14 days |
Please be aware that the following tests may be requested as further testing, based on the clinical details included in the request and clinical approval:
- Crithidia (TAT 18 days)
- Extended myositis panel (TAT 25 days)
- Nucleosomes (TAT 40 days)
- Histones and (TAT (31 days)
- Extended Scleroderma panel (TAT 25 days)
